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PLoS One. 2018 Mar 29;13(3):e0191791. doi: 10.1371/journal.pone.0191791. eCollection 2018.

The 'COmorBidity in Relation to AIDS' (COBRA) cohort: Design, methods and participant characteristics.

Author information

1
University College London, London, United Kingdom.
2
Academisch Medisch Centrum, Universiteit van Amsterdam, Amsterdam, The Netherlands.
3
Stichting HIV Monitoring, Amsterdam, The Netherlands.
4
Imperial College London, London, United Kingdom.
5
GGD Amsterdam, Public Health Service Amsterdam, Amsterdam, The Netherlands.
6
Università degli studi di Modena e Reggio Emilia, Modena, Italy.
7
Stichting Katholieke Universiteit Nijmegen, Nijmegen, The Netherlands.
8
Alma Mater Studiorum Universita di Bologna, Bologna, Italy.
9
Vlaams Instituut voor Biotechnologie, Ghent, Belgium.
10
Universität Konstanz, Konstanz, Germany.

Abstract

BACKGROUND:

Persons living with HIV on combination antiretroviral therapy (cART) may be at increased risk of the development of age-associated non-communicable comorbidities (AANCC) at relatively young age. It has therefore been hypothesised that such individuals, despite effective cART, may be prone to accelerated aging.

OBJECTIVE:

The COmorBidity in Relation to AIDS (COBRA) cohort study was designed to investigate the potential causal link between HIV and AANCC, amongst others, in a cohort of middle-aged individuals with HIV with sustained viral suppression on cART and otherwise comparable HIV-negative controls.

METHODS:

Longitudinal cohort study of HIV-positive subjects ≥45 years of age, with sustained HIV suppression on cART recruited from two large European HIV treatment centres and similarly-aged HIV-negative controls recruited from sexual health centres and targeted community groups. Both HIV-positive and HIV-negative subjects were assessed at study entry and again at follow-up after 2 years.

RESULTS:

Of the 134 HIV-positive individuals with a median (IQR) age of 56 (51, 62) years recruited, 93% were male, 88% of white ethnicity and 86% were men who have sex with men (MSM). Similarly, the 79 HIV-negative subjects had a median (IQR) age of 57 (52, 64) and 92% were male, 97% of white ethnicity and 80% were MSM.

CONCLUSIONS:

The results from the COBRA study will be a significant resource to understand the link between HIV and AANCC and the pathogenic mechanisms underlying this link. COBRA will inform future development of novel prognostic tools for earlier diagnosis of AANCC and of novel interventions which, as an adjunct to cART, may prevent AANCC.

PMID:
29596425
PMCID:
PMC5875743
DOI:
10.1371/journal.pone.0191791
[Indexed for MEDLINE]
Free PMC Article

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