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Pediatr Infect Dis J. 2019 Feb;38(2):164-168. doi: 10.1097/INF.0000000000002042.

Dietary Supplementation With Medium-Chain Triglycerides Reduces Candida Gastrointestinal Colonization in Preterm Infants.

Author information

1
From the Department of Pediatrics, Women & Infants Hospital of Rhode Island.
2
Warren Alpert Medical School of Brown University, Providence, Rhode Island.
3
Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts.
4
Department of Biology, Siena College, Loudonville, New York.
5
Cardiovascular Nutrition Laboratory, JM USDA Human Nutrition Research Center, Tufts University, Boston, Massachusetts.

Abstract

BACKGROUND:

Candida is an important cause of infections in premature infants. Gastrointestinal colonization with Candida is a common site of entry for disseminated disease. The objective of this study was to determine whether a dietary supplement of medium-chain triglycerides (MCTs) reduces Candida colonization in preterm infants.

METHODS:

Preterm infants with Candida colonization (n = 12) receiving enteral feedings of either infant formula (n = 5) or breast milk (n = 7) were randomized to MCT supplementation (n = 8) or no supplementation (n = 4). Daily stool samples were collected to determine fungal burden during a 3-week study period. Infants in the MCT group received supplementation during 1 week of the study period. The primary outcome was fungal burden during the supplementation period as compared with the periods before and after supplementation.

RESULTS:

Supplementation of MCT led to a marked increase in MCT intake relative to unsupplemented breast milk or formula as measured by capric acid content. In the treatment group, there was a significant reduction in fungal burden during the supplementation period as compared with the period before supplementation (rate ratio, 0.15; P = 0.02), with a significant increase after supplementation was stopped (rate ratio, 61; P < 0.001). Fungal burden in the control group did not show similar changes.

CONCLUSIONS:

Dietary supplementation with MCT may be an effective method to reduce Candida colonization in preterm infants.

PMID:
29596218
PMCID:
PMC6604858
[Available on 2020-02-01]
DOI:
10.1097/INF.0000000000002042

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