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Mikrochim Acta. 2017 Dec 26;185(1):78. doi: 10.1007/s00604-017-2551-2.

Voltammetric lidocaine sensor by using a glassy carbon electrode modified with porous carbon prepared from a MOF, and with a molecularly imprinted polymer.

Author information

1
Key Laboratory of Xinjiang Phytomedicine Resource and Utilization, Ministry of Education, Shihezi University, Shihezi, 832000, China.
2
College of Science, Harbin Institute of Technology, Shenzhen, 518055, China.
3
Key Laboratory for Green Processing of Chemical Engineering of Xinjiang Bingtuan, School of Chemistry and Chemical Engineering, Shihezi University, Shihezi, 832003, China.
4
Laboratory of Environmental Science and Technology, The Xinjiang Technical Institute of Physics and Chemistry; Key Laboratory of Functional Materials and Devices for Special Environments, Chinese Academy of Sciences, Urumqi, 830011, China.
5
College of Optoelectronic Engineering, Shenzhen University, Shenzhen, 518060, China. zcpeng@szu.edu.cn.
6
College of Science, Harbin Institute of Technology, Shenzhen, 518055, China. liyingchun@hit.edu.cn.

Abstract

The work describes a hybrid electrochemical sensor for highly sensitive detection of the anesthetic lidocaine (LID). Porous carbon (PC) was synthesized from an isoreticular metal-organic framework-8 (IRMOF-8) and drop cast onto a glassy carbon electrode (GCE). A layer of a molecularly imprinted polymer (MIP) layer was then fabricated in situ on the modified GCE by electro-polymerization, with LID acting as the template and resorcinol as the functional monomer. Hexacyanoferrate is used as an electrochemical probe. The electrical signal (typically acquired at 0.335 V vs. SCE) increases linearly in the 0.2 pM to 8 nM LID concentration range, with a remarkable 67 fM detection limit (at an S/N ratio of 3). The sensor is stable and selective. Eventually, rapid and accurate detection of LID in spiked real samples was successfully realized. Graphical abstract ᅟ.

KEYWORDS:

Brunauer-Emmett-Teller; Cyclic voltammetry; Electrochemical sensor; Hexacyanoferrate; MOF derived carbon; Nanoporous material; Raman spectra; Scanning electron microscopy; Trace measurement; X-ray photoelectron spectroscopy

PMID:
29594562
DOI:
10.1007/s00604-017-2551-2

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