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Mikrochim Acta. 2017 Dec 26;185(1):78. doi: 10.1007/s00604-017-2551-2.

Voltammetric lidocaine sensor by using a glassy carbon electrode modified with porous carbon prepared from a MOF, and with a molecularly imprinted polymer.

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Key Laboratory of Xinjiang Phytomedicine Resource and Utilization, Ministry of Education, Shihezi University, Shihezi, 832000, China.
College of Science, Harbin Institute of Technology, Shenzhen, 518055, China.
Key Laboratory for Green Processing of Chemical Engineering of Xinjiang Bingtuan, School of Chemistry and Chemical Engineering, Shihezi University, Shihezi, 832003, China.
Laboratory of Environmental Science and Technology, The Xinjiang Technical Institute of Physics and Chemistry; Key Laboratory of Functional Materials and Devices for Special Environments, Chinese Academy of Sciences, Urumqi, 830011, China.
College of Optoelectronic Engineering, Shenzhen University, Shenzhen, 518060, China.
College of Science, Harbin Institute of Technology, Shenzhen, 518055, China.


The work describes a hybrid electrochemical sensor for highly sensitive detection of the anesthetic lidocaine (LID). Porous carbon (PC) was synthesized from an isoreticular metal-organic framework-8 (IRMOF-8) and drop cast onto a glassy carbon electrode (GCE). A layer of a molecularly imprinted polymer (MIP) layer was then fabricated in situ on the modified GCE by electro-polymerization, with LID acting as the template and resorcinol as the functional monomer. Hexacyanoferrate is used as an electrochemical probe. The electrical signal (typically acquired at 0.335 V vs. SCE) increases linearly in the 0.2 pM to 8 nM LID concentration range, with a remarkable 67 fM detection limit (at an S/N ratio of 3). The sensor is stable and selective. Eventually, rapid and accurate detection of LID in spiked real samples was successfully realized. Graphical abstract ᅟ.


Brunauer-Emmett-Teller; Cyclic voltammetry; Electrochemical sensor; Hexacyanoferrate; MOF derived carbon; Nanoporous material; Raman spectra; Scanning electron microscopy; Trace measurement; X-ray photoelectron spectroscopy


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