Uptake of Prostate-Specific Membrane Antigen (PSMA) in adenoid cystic carcinoma - Is PSMA-PET-CT a helpful tool in radiation oncology?

Laila König; Henrik Hauswald; Christa Flechtenmacher; Martina Heller; Jürgen Debus; Uwe Haberkorn; Clemens Kratochwil; Frederik Giesel

doi:10.1016/j.ctro.2017.10.003

Uptake of Prostate-Specific Membrane Antigen (PSMA) in adenoid cystic carcinoma - Is PSMA-PET-CT a helpful tool in radiation oncology?

Clin Transl Radiat Oncol. 2017 Nov 14:7:79-82. doi: 10.1016/j.ctro.2017.10.003. eCollection 2017 Dec.

Authors

Laila König^{1

2}, Henrik Hauswald^{1

2}, Christa Flechtenmacher³, Martina Heller⁴, Jürgen Debus^{1

2}, Uwe Haberkorn⁵, Clemens Kratochwil⁵, Frederik Giesel⁵

Affiliations

¹ Department of Radiation Oncology, Heidelberg University Hospital, INF 400, 69120 Heidelberg, Germany.
² Heidelberg Institute for Radiation Oncology (HIRO), Heidelberg, Germany.
³ Institute of Pathology, Heidelberg University Hospital, INF 224, 69120 Heidelberg, Germany.
⁴ Section of Molecular Urooncology, Department of Urology, Heidelberg University Hospital, INF 517, 69120 Heidelberg, Germany.
⁵ Department of Nuclear Medicine, Heidelberg University Hospital, INF 400, 69120 Heidelberg, Germany.

Abstract

This case report shows the high PSMA-uptake in a patient with an adenoid cystic carcinoma of the maxillary sinus. Due to the intense ligand-uptake additional information for target volume delineation was obtained and the Treatment plan for bimodal radiotherapy with carbon ions was adapted accordingly.

Keywords: ACC, Adenoid cystic carcinoma; CTCAE, Common terminology criteria of adverse events; HIT, Heidelberg Ion Beam Therapy Center; IHC, Immunohistochemistry; IMRT, intensity modulated radiotherapy; PET-CT, Positron emission tomography-computed tomography; PSMA, Prostate-Specific Membrane Antigen; RBE, Relative Biological Effectiveness; RECIST, Response Evaluation Criteria In Solid Tumors; RT, radiotherapy.

Publication types

Case Reports