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Front Pharmacol. 2018 Mar 9;9:200. doi: 10.3389/fphar.2018.00200. eCollection 2018.

East Indian Sandalwood Oil Is a Phosphodiesterase Inhibitor: A New Therapeutic Option in the Treatment of Inflammatory Skin Disease.

Author information

1
The Vancouver Prostate Centre, Vancouver Coastal Health Research Institute, Vancouver, BC, Canada.
2
Santalis Pharmaceuticals, Inc., San Antonio, TX, United States.
3
Texas Dermatology and Laser Specialists, San Antonio, TX, United States.
4
Department of Urologic Sciences, The University of British Columbia, Vancouver, BC, Canada.

Abstract

Cyclic adenosine monophosphate phosphodiesterases (PDEs) regulate pro-inflammatory cytokine production. One isoform, PDE4, is overactive in chronic relapsing inflammatory skin diseases: psoriasis and eczema/atopic dermatitis, and in several cancers. East Indian sandalwood oil (EISO) has significant anti-inflammatory properties. Here, we report that 75% of pediatric eczema/atopic dermatitis patients treated with topical EISO formulations achieved a >50% reduction in their Eczema Area and Severity Index score. EISO treatment of a psoriasis model reduced PDE4 expression and reversed histopathology. EISO directly inhibited PDE enzymatic activity in vitro. In lipopolysaccharide-stimulated human dermal fibroblast, BEAS-2B, A549, and THP-1 cells, EISO suppressed total cellular PDE activity, PDE4, and 7 transcript levels, nuclear factor kappa B (NF-κB) activation, and pro-inflammatory cytokines/chemokine production. These results suggest that EISO anti-inflammatory activity is mediated through suppressing PDE activity, thus facilitating cAMP-regulated inhibition of NF-κB and indicate EISO as an attractive natural therapeutic for chronic and acute inflammatory disorders.

KEYWORDS:

anti-inflammatory; anti-proliferative; atopic dermatitis; cancer; eczema; phosphodiesterase; psoriasis; skin organoid

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