Format

Send to

Choose Destination
Dis Model Mech. 2018 Feb 26;11(2). pii: dmm032151. doi: 10.1242/dmm.032151.

Use of zebrafish to study Shigella infection.

Author information

1
Section of Microbiology, MRC Centre for Molecular Bacteriology and Infection, Imperial College London, London SW7 2AZ, UK.
2
Section of Microbiology, MRC Centre for Molecular Bacteriology and Infection, Imperial College London, London SW7 2AZ, UK s.mostowy@imperial.ac.uk.

Abstract

Shigella is a leading cause of dysentery worldwide, responsible for up to 165 million cases of shigellosis each year. Shigella is also recognised as an exceptional model pathogen to study key issues in cell biology and innate immunity. Several infection models have been useful to explore Shigella biology; however, we still lack information regarding the events taking place during the Shigella infection process in vivo Here, we discuss a selection of mechanistic insights recently gained from studying Shigella infection of zebrafish (Danio rerio), with a focus on cytoskeleton rearrangements and cellular immunity. We also discuss how infection of zebrafish can be used to investigate new concepts underlying infection control, including emergency granulopoiesis and the use of predatory bacteria to combat antimicrobial resistance. Collectively, these insights illustrate how Shigella infection of zebrafish can provide fundamental advances in our understanding of bacterial pathogenesis and vertebrate host defence. This information should also provide vital clues for the discovery of new therapeutic strategies against infectious disease in humans.

KEYWORDS:

Antimicrobial resistance; Autophagy; Cytoskeleton; Emergency granulopoiesis; Inflammation; Macrophage; Neutrophil; Septin; Shigella; Zebrafish

PMID:
29590642
PMCID:
PMC5894947
DOI:
10.1242/dmm.032151
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center