Format

Send to

Choose Destination
Biophys J. 2018 Mar 27;114(6):1477-1489. doi: 10.1016/j.bpj.2018.01.035.

Tissue-Specific Optical Mapping Models of Swine Atria Informed by Optical Coherence Tomography.

Author information

1
Department of Electrical Engineering, Columbia University, New York, New York.
2
Department of Bioengineering, University of California San Diego, San Diego, California.
3
Department of Electrical Engineering, Columbia University, New York, New York. Electronic address: cpf2115@columbia.edu.

Abstract

Computational models and experimental optical mapping of cardiac electrophysiology serve as powerful tools to investigate the underlying mechanisms of arrhythmias. Modeling can also aid the interpretation of optical mapping signals, which may have different characteristics with respect to the underlying electrophysiological signals they represent. However, despite the prevalence of atrial arrhythmias such as atrial fibrillation, models of optical electrical mapping incorporating realistic structure of the atria are lacking. Therefore, we developed image-based models of atrial tissue using structural information extracted from optical coherence tomography (OCT), which can provide volumetric tissue characteristics in high resolution. OCT volumetric data of four swine atrial tissue samples were used to develop models incorporating tissue geometry, tissue-specific myofiber orientation, and ablation lesion regions. We demonstrated the use of these models through electrophysiology and photon scattering simulations. Changes in transmural electrical conduction were observed with the inclusion of OCT-derived, depth-resolved fiber orientation. Additionally, the amplitude of optical mapping signals were not found to correspond with lesion transmurality because of lesion geometry and electrical propagation occurring beyond excitation light penetration. This work established a framework for the development of tissue-specific models of atrial tissue derived from OCT imaging data, which can be useful in future investigations of electrophysiology and optical mapping signals with respect to realistic atrial tissue structure.

PMID:
29590604
PMCID:
PMC5883619
DOI:
10.1016/j.bpj.2018.01.035
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center