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Eur J Nutr. 2019 Mar;58(2):619-627. doi: 10.1007/s00394-018-1647-8. Epub 2018 Mar 27.

Dairy products intake and the risk of incident cataracts surgery in an elderly Mediterranean population: results from the PREDIMED study.

Author information

1
Human Nutrition Unit, Biochemistry and Biotechnology Department, Faculty of Medicine and Health Sciences, University Hospital of Sant Joan de Reus, IISPV, Universitat Rovira i Virgili, St/Sant Llorenç 21, 43201, Reus, Spain.
2
CIBERobn Physiopathology of Obesity and Nutrition, Institute of Health Carlos III, Madrid, Spain.
3
Human Nutrition Unit, Biochemistry and Biotechnology Department, Faculty of Medicine and Health Sciences, University Hospital of Sant Joan de Reus, IISPV, Universitat Rovira i Virgili, St/Sant Llorenç 21, 43201, Reus, Spain. monica.bullo@urv.cat.
4
CIBERobn Physiopathology of Obesity and Nutrition, Institute of Health Carlos III, Madrid, Spain. monica.bullo@urv.cat.
5
Department of Preventive Medicine and Public Health, Medical School, University of Navarra, Pamplona, Spain.
6
Department of Preventive Medicine, University of Valencia, Valencia, Spain.
7
Department of Internal Medicine, August Pi i Sunyer Institute of Biomedical Research (IDIBAPS), Hospital Clinic, University of Barcelona, Barcelona, Spain.
8
Cardiovascular Risk and Nutrition, Regicor Study Group, Hospital del Mar Medical Research Institute, Barcelona Biomedical Research Park, Barcelona, Spain.
9
Department of Preventive Medicine, University of Malaga, Malaga, Spain.
10
Department of Cardiology, University Hospital Araba, Vitoria, Spain.
11
Department of Cardiology, University Hospital Son Dureta, Palma de Mallorca, Spain.
12
Department of Family Medicine, San Pablo Health Center, Sevilla, Spain.
13
Research Institute of Biomedical and Health Sciences, University of Las Palmas de Gran Canaria, Las Palmas, Spain.
14
Lipids and Vascular Risk Unit, Internal Medicine, University Hospital of Bellvitge, Barcelona, Spain.
15
Emergency Department, Navarra's Hospital Complex, National Health Service-Osasunbidea, Pamplona, Spain.
16
Primary Health Care Division, Institut Català de la Salut and Idiap-Jordi Gol, Barcelona, Spain.
17
Ophthalmic Research Unit "Santiago Grisolía" Valencia, Valencia, Spain.
18
Red Temática de Patología Ocular OFTARED, ISCIII, Madrid, Spain.
19
Department of Ophthalmology, University of Navarra, Pamplona, Spain.
20
Human Nutrition Unit, Biochemistry and Biotechnology Department, Faculty of Medicine and Health Sciences, University Hospital of Sant Joan de Reus, IISPV, Universitat Rovira i Virgili, St/Sant Llorenç 21, 43201, Reus, Spain. jordi.salas@urv.cat.
21
CIBERobn Physiopathology of Obesity and Nutrition, Institute of Health Carlos III, Madrid, Spain. jordi.salas@urv.cat.

Abstract

PROPOSAL:

The aim of this study was to examine the association between the consumption of total and specific types of dairy products and the risk of incident cataracts in an elderly Mediterranean population at high cardiovascular risk.

METHODS:

We prospectively analyzed 5860 subjects from the PREvención con DIeta MEDiterránea (PREDIMED) Study. The time to cataract surgery was calculated as the time between recruitment and the date of the surgery, last visit of the follow-up, date of death, or until the end of the study. Dairy products intake was assessed using validated food frequency questionnaires. We used Cox proportional hazard regression to assess the risk of cataract surgery according to average dietary energy-adjusted total dairy products, milk, yogurt and cheese consumption.

RESULTS:

We documented a total of 768 new cataract events after a median of 5.6 years of follow-up. Subjects in the second [hazard ratio (HR) 0.62; 95% CI 0.52, 0.74] and third tertile (HR: 0.71; 95% CI 0.60, 0.85) of skimmed yogurt intake had a significantly lower risk of cataracts after adjusting for potential confounders. No significant associations were observed for total dairy products, whole and skimmed milk, whole yogurt and cheese consumption.

CONCLUSION:

The intake of skimmed yogurt was associated with a reduced risk of cataracts in an elderly Mediterranean population with high cardiovascular risk. No significant associations were observed for other type of dairy product.

CLINICAL TRIAL REGISTRATION:

International Standard Randomized Controlled Trial Number (ISRCTN): 35739639. Registration date: 5 October 2005.

KEYWORDS:

Cataracts; Dairy; Epidemiology; PREDIMED; Yogurt

PMID:
29589119
DOI:
10.1007/s00394-018-1647-8

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