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BMC Anesthesiol. 2018 Mar 27;18(1):31. doi: 10.1186/s12871-018-0496-6.

The attenuation of neurological injury from the use of simvastatin after spinal cord ischemia-reperfusion injury in rats.

Ryu JH1,2, Park JW1,2, Hwang JY1,3, Park SJ1,2, Kim JH1,2, Sohn HM1,2, Han SH4,5.

Author information

1
Department of Anesthesiology and Pain Medicine, Seoul National University College of Medicine, Seoul, South Korea.
2
Department of Anesthesiology and Pain Medicine, Seoul National University Bundang Hospital, Seong-nam, South Korea.
3
Department of Anesthesiology and Pain Medicine, SNU-SMG hospital, Seoul, South Korea.
4
Department of Anesthesiology and Pain Medicine, Seoul National University College of Medicine, Seoul, South Korea. anesthesiology@snubh.org.
5
Department of Anesthesiology and Pain Medicine, Seoul National University Bundang Hospital, Seong-nam, South Korea. anesthesiology@snubh.org.

Abstract

BACKGROUND:

Spinal cord ischemic injury remains a serious complication of open surgical and endovascular aortic procedures. Simvastatin has been reported to be associated with neuroprotective effect after spinal cord ischemia-reperfusion (IR) injury. The aim of this study was to determine the therapeutic efficacy of starting simvastatin after spinal cord IR injury in a rat model.

METHODS:

In adult Sprague-Dawley rats, spinal cord ischemia was induced using a balloon-tipped catheter placed in the descending thoracic aorta. The animals were then randomly divided into 4 groups: group A (control); group B (0.5 mg/kg simvastatin); group C (1 mg/kg simvastatin); and group D (10 mg/kg simvastatin). Simvastatin was administered orally upon reperfusion for 5 days. Neurological function of the hind limbs was evaluated for 7 days after reperfusion and recorded using a motor deficit score (MDS) (0: normal, 5: complete paraplegia). The number of normal motor neurons within the anterior horns of the spinal cord was counted after final MDS evaluation. Then, the spinal cord was harvested for histopathological examination.

RESULTS:

Group D showed a significantly lower MDS than the other groups at post-reperfusion day 1 and this trend was sustained throughout the study period. Additionally, a greater number of normal motor neurons was observed in group D than in other groups (group D 21.2 [3.2] vs. group A: 15.8 [4.2]; group B 15.4 [3.4]; and group C 15.5 [3.7]; P = 0.002).

CONCLUSIONS:

The results of the current study suggest that 10 mg/kg can significantly improve neurologic outcome by attenuating neurologic injury and restoring normal motor neurons after spinal cord IR injury.

KEYWORDS:

Neuroprotection; Reperfusion injury; Simvastatin; Thoracoabdominal aortic surgery

PMID:
29587636
PMCID:
PMC5869785
DOI:
10.1186/s12871-018-0496-6
[Indexed for MEDLINE]
Free PMC Article

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