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Pharmacology. 2018;101(5-6):285-289. doi: 10.1159/000487954. Epub 2018 Mar 27.

Functions of the Signal Transducer and Activator of Transcription 6 in a Behavioral Animal Model of Depression.

Author information

1
Department of Pharmacology, College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea.
2
Department of Life and Nanopharmaceutical Science, Kyung Hee East-West Pharmaceutical Research Institute, College of Pharmacy, Kyung Hee University, Seoul, Republic of Korea.
3
Department of Pharmaceutical Engineering, Hoseo University, Asan, Republic of Korea.
4
Department of Food Science and Technology, Hoseo University, Asan, Republic of Korea.

Abstract

AIMS:

Depression is one of the most common inflammatory and mental disorders. Signal transducer and activator of transcription 6 (STAT6) plays a crucial role in the pathology of mental disorders as well as inflammatory diseases.

METHODS:

Here we determined the role of STAT6 in the pathogenesis of depression using STAT6-deficient mice in a forced swimming test.

RESULTS:

The immobility time was significantly decreased in STAT6-deficient mice compared to wild-type mice without alteration of locomotor activity. STAT6-deficient mice exhibited a significantly enhancing dopamine and 5-hydroxytryptamine (5-HT, serotonin) in brain. In addition, the expression of serotonin transporter in the hippocampus was markedly downregulated in STAT6-deficient mice. These results provide the first evidence that STAT6 affects depressive-like behavior through downregulating monoamines, including dopamine and 5-HT in the hippocampus of brain.

CONCLUSIONS:

In conclusion, identification of STAT6 signaling pathways on depression might open new perspectives for antidepressant therapies.

KEYWORDS:

Depression; Dopamine; Serotonin; Signal transducer and activator of transcription 6

PMID:
29587269
DOI:
10.1159/000487954
[Indexed for MEDLINE]

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