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Arch Gerontol Geriatr. 2018 Jul - Aug;77:8-12. doi: 10.1016/j.archger.2017.12.010. Epub 2017 Dec 24.

Prescription of potentially inappropriate medications to older adults. A nationwide survey at dispensing pharmacies in Japan.

Author information

1
Center for Community Liaison and Patient Consultations, Nagoya University Hospital, Japan. Electronic address: yus@med.nagoya-u.ac.jp.
2
Sugi Pharmacy Co., Ltd, Japan.
3
Department of Rehabilitation, Faculty of Health Sciences, Nihon Fukushi University, Japan.
4
Department of Community Healthcare and Geriatrics, Nagoya University Graduate School of Medicine, Japan.
5
Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, Japan.

Abstract

OBJECTIVES:

Prescriptions to older adults were surveyed to elucidate factors associated with potentially inappropriate medications (PIMs) in Japan.

METHODS:

Adults aged ≥65 years, who were prescribed medications at 585 dispensing pharmacies across Japan, participated (N = 180,673). Data were collected between October 1 and October 31, 2014.

RESULTS:

Proportion of polypharmacy and that of PIMs increased with age (p < 0.001). Analgesic drugs were most commonly prescribed for the older adults aged 65-74 years, whereas benzodiazepines were prescribed most commonly for those aged over 75 years. A logistic regression analysis revealed that the increase of PIMs was explained by polypharmacy and mainly the use of central nervous systems (CNS) and psychotropic drugs.

CONCLUSIONS:

The increased prevalence of polypharmacy with age and the common use of CNS and psychotropic medications account for the PIMs in old age in the current nationwide survey.

KEYWORDS:

Dispensing pharmacies; Nationwide survey; Potentially inappropriate medications

PMID:
29587175
DOI:
10.1016/j.archger.2017.12.010
[Indexed for MEDLINE]

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