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Eur Arch Otorhinolaryngol. 2018 May;275(5):1289-1300. doi: 10.1007/s00405-018-4949-9. Epub 2018 Mar 26.

Expression of hormone receptors in oropharyngeal squamous cell carcinoma.

Author information

1
Department of Pathology, University of Helsinki, HusLab and Helsinki University Hospital, Haartmaninkatu 3, P.O. Box 21, 00014, Helsinki, Finland. hesham.mohamed@helsinki.fi.
2
Department of Histology, Omar Al-Mukhtar University, AlBayda, Libya. hesham.mohamed@helsinki.fi.
3
Department of Otorhinolaryngology, Head and Neck Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
4
Division of Ear, Nose and Throat Diseases, Department of Clinical Sciences, Intervention and Technology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
5
Department of Pathology, University of Helsinki, HusLab and Helsinki University Hospital, Haartmaninkatu 3, P.O. Box 21, 00014, Helsinki, Finland.
6
Department of Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
7
Research Programs Unit, Translational Cancer Biology, University of Helsinki, Helsinki, Finland.

Abstract

OBJECTIVES:

Hormone receptors play an important role in many types of cancers. Alongside factors associated with human papillomavirus (HPV) infection, hormonal receptors may impact the tumorigenesis of oropharyngeal cancer.

MATERIALS AND METHODS:

This study consists of 199 consecutive oropharyngeal squamous cell carcinoma (OPSCC) patients diagnosed and treated with a curative intent. We examined androgen (AR), estrogen (ER; both alpha and beta), and progesterone receptor (PR) expressions using immunohistochemistry comparing tumor and patient characteristics.

RESULTS:

AR was expressed in 16%, PR in 27% and ER-beta in 63% of the tumors. HPV- and p16-positive tumors expressed more AR and less PR than their negative counterparts. High PR expression was associated with poor disease-specific and locoregional recurrence-free survival.

CONCLUSION:

AR, PR, and ER-beta are expressed in OPSCC, and AR and PR expressions are associated with HPV and p16 status. Furthermore, PR appears to have prognostic significance. This may allow us to investigate the role of anti-hormone receptors in the treatment of OPSCC.

KEYWORDS:

Androgen receptor; Estrogen receptor; Human papillomavirus (HPV); Oropharynx; Progesterone receptor

PMID:
29582173
DOI:
10.1007/s00405-018-4949-9
[Indexed for MEDLINE]

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