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J Lifestyle Med. 2018 Jan;8(1):1-7. doi: 10.15280/jlm.2018.8.1.1. Epub 2018 Jan 31.

Influence of Altered Gut Microbiota Composition on Aging and Aging-Related Diseases.

Choi J1,2,3, Hur TY4, Hong Y1,2,3,5.

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Department of Rehabilitation Science, Graduate School, Inje University, Gimhae, Korea.
Biohealth Products Research Center (BPRC), Inje University, Gimhae, Korea.
Ubiquitous Healthcare & Anti-aging Research Center (u-HARC), Inje University, Gimhae, Korea.
Animal Biotechnology Division, National Institute of Animal Science, Wanju, Korea.
Department of Physical Therapy, College of Healthcare Medical Science & Engineering, Inje University, Gimhae, Korea.


The gut microbiota forms a large community that coexists with all species, including humans and rodents. Genome projects have been conducted by many researchers in nearly every country to better understand and treat diseases that lead to death in humans. However, the gut microbiota is known as a "second genome" because it includes microbes, genomic DNA, proteins, and metabolites. A large number of studies have revealed the importance of the gut microbiota. In elderly people, the diversity of the gut microbiota is reduced and there is an increased incidence of degenerative diseases, including Alzheimer's and Parkinson's, and decreased cognitive and memory functions. However, the administration of pre/probiotics can help to improve the symptoms of these diseases. Therefore, we believe that the gut microbiota is important for maintaining homeostasis and diversity, as well as for avoiding gastrointestinal tract-derived diseases and improving health in the elderly population.


Aging; Degenerative diseases; Elderly people; Gastrointestinal tract; Gut microbiota

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