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Oncotarget. 2018 Feb 6;9(18):14680-14691. doi: 10.18632/oncotarget.24411. eCollection 2018 Mar 6.

Old Sonic Hedgehog, new tricks: a new paradigm in thoracic malignancies.

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Department of Respiratory Diseases and Thoracic Oncology, APHP - Ambroise Paré Hospital, Boulogne-Billancourt, France.
EA 4340 BCOH, UVSQ, Paris-Saclay University, Boulogne-Billancourt, France.
Thoracic Oncology Program, Department of Surgery, Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, California, USA.


The Sonic Hedgehog (Shh) pathway is physiologically involved during embryogenesis, but is also activated in several diseases, including solid cancers. Previous studies have demonstrated that the Shh pathway is involved in oncogenesis, tumor progression and chemoresistance in lung cancer and mesothelioma. The Shh pathway is also closely associated with epithelial-mesenchymal transition and cancer stem cells. Recent findings have revealed that a small proportion of lung cancer cells expressed an abnormal full-length Shh protein, associated with cancer stem cell features. In this paper, we review the role of the Shh pathway in thoracic cancers (small cell lung cancer, non-small cell lung cancer, and mesothelioma) and discuss the new perspectives of cancer research highlighted by the recent data of the literature.


Sonic Hedgehog; cancer stem cell; chemoresistance; lung cancer; mesothelioma

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