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Sci Rep. 2018 Mar 26;8(1):5155. doi: 10.1038/s41598-018-23408-0.

Modeling the effects of lipid peroxidation during ferroptosis on membrane properties.

Author information

1
Department of Biological Sciences, MC4846, Columbia University, 550 West 120th Street, New York, NY, 10027, USA.
2
Laboratoire Physico Chimie Curie, Institut Curie, PSL Research University, CNRS UMR168, 75005, Paris, France.
3
Sorbonne Université, 75005, Paris, France.
4
Center for Genomic Regulation, The Barcelona Institute of Science and Technology, Barcelona, Spain.
5
Universitat Pompeu Fabra, Barcelona, Spain.
6
Department of Biological Sciences, MC4846, Columbia University, 550 West 120th Street, New York, NY, 10027, USA. bstockwell@columbia.edu.
7
Department of Chemistry, MC4846, Columbia University, 550 West 120th Street, New York, NY, 10027, USA. bstockwell@columbia.edu.

Abstract

Ferroptosis is a form of regulated cell death characterized by the accumulation of lipid hydroperoxides. There has been significant research on the pathways leading to the accumulation of oxidized lipids, but the downstream effects and how lipid peroxides cause cell death during ferroptosis remain a major puzzle. We evaluated key features of ferroptosis in newly developed molecular dynamics models of lipid membranes to investigate the biophysical consequences of lipid peroxidation, and generated hypotheses about how lipid peroxides contribute to cell death during ferroptosis.

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