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RNA. 2018 Jun;24(6):761-768. doi: 10.1261/rna.065508.117. Epub 2018 Mar 26.

HnRNP L represses cryptic exons.

Author information

1
Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6059, USA.
2
Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205-2196, USA.

Abstract

The fidelity of RNA splicing is regulated by a network of splicing enhancers and repressors, although the rules that govern this process are not yet fully understood. One mechanism that contributes to splicing fidelity is the repression of nonconserved cryptic exons by splicing factors that recognize dinucleotide repeats. We previously identified that TDP-43 and PTBP1/PTBP2 are capable of repressing cryptic exons utilizing UG and CU repeats, respectively. Here we demonstrate that hnRNP L (HNRNPL) also represses cryptic exons by utilizing exonic CA repeats, particularly near the 5'SS. We hypothesize that hnRNP L regulates CA repeat repression for both cryptic exon repression and developmental processes such as T cell differentiation.

KEYWORDS:

HNRNPL; HnRNP L; alternative splicing; cryptic exons; dinucleotide repeats

PMID:
29581412
PMCID:
PMC5959245
[Available on 2019-06-01]
DOI:
10.1261/rna.065508.117
[Indexed for MEDLINE]

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