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Therapie. 2018 Apr;73(2):151-156. doi: 10.1016/j.therap.2017.11.009. Epub 2018 Feb 21.

Pharmacoepidemiology in pediatrics: Needs, challenges and future directions for research.

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Department of medical informatics, Erasmus university medical center, 3015 GE Rotterdam, The Netherlands.
Inserm, CIC 1426, 75019 Paris, France; Université Paris Diderot, Sorbonne Paris Cité, EA 08, 75010 Paris, France; Robert-Debré hospital, department of pediatric pharmacology and pharmacogenetics, AP-HP, 75019 Paris, France. Electronic address:


Despite international initiatives to promote clinical research in pediatrics, there are still many gaps of knowledge in the use of drugs to treat this specific population. When important information cannot be derived only from clinical trials, use of available observational research tools is required. In this paper, we provide an overview of the particular interest of pharmacoepidemiological research into the evaluation of drug effects in children and adolescents. We also sought to underline the unique challenges and specific needs regarding this research. Implementation of innovative methodologies and expansion of database networks to perform necessary studies could further improve performances of observational research.


Challenges; Drug development; Pediatrics; Pharmacoepidemiology

[Indexed for MEDLINE]

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