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J Invest Dermatol. 2018 Apr;138(4):731-734. doi: 10.1016/j.jid.2017.12.008.

Topical Gentamicin for the Treatment of Genetic Skin Diseases.

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1
Department of Dermatology, Center of Expertise of Blistering Diseases, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. Electronic address: a.m.g.pasmooij@umcg.nl.

Abstract

Clinical application of topical gentamicin is a worthwhile option to investigate further for Nagashima-type palmoplantar keratosis and other genetic skin diseases caused by nonsense mutations. It is especially interesting to study gentamicin 1B because it may be more efficacious than other gentamicin components. Topical gentamicin has an acceptable safety profile, although prospective tracking of antibiotic resistance is warranted.

PMID:
29579455
DOI:
10.1016/j.jid.2017.12.008
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