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ERJ Open Res. 2018 Mar 20;4(1). pii: 00121-2017. doi: 10.1183/23120541.00121-2017. eCollection 2018 Jan.

Pseudoneutropenia in lymphangioleiomyomatosis (LAM) patients receiving sirolimus: evaluation in a 100 patient cohort.

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Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Rush Medical College, Rush University Medical Center, Chicago, IL, USA.
Critical Care Medicine Dept, NIH Clinical Center, Bethesda, MD, USA.
Division of Pulmonary, Critical Care and Sleep Medicine, National Jewish Health, Denver, CO, USA.
Division of Respiratory, Critical Care and Occupational Pulmonary Medicine, Dept of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, UT, USA.
Dept of Laboratory Medicine, NIH Clinical Center, Bethesda, MD, USA.


In lymphangioleiomyomatosis patients receiving sirolimus treatment, transient leukopenia in the morning may be due to circadian rhythm, with leukocyte counts recovering later in the day, indicating that a decrease in drug dose may not be warranted

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