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J Clin Transl Hepatol. 2018 Mar 28;6(1):85-88. doi: 10.14218/JCTH.2017.00042. Epub 2017 Oct 27.

Activation of Anti-tumor Immune Response by Ablation of HCC with Nanosecond Pulsed Electric Field.

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Collaborative Innovation Center for Diagnosis Treatment of Infectious Diseases, Key Laboratory of Combined Multi-organ Transplantation, Ministry of Public Health, Department of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital, Zhejiang University, Hangzhou, Zhejiang, China.
Department of Anatomy, Tianjin Medical University, Tianjin, China.
Hepatobiliary & Hydatid Department, Digestive and Vascular Surgery Centre, Xinjiang Key Laboratory of Echinococcosis, First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.
Department of Orthopedics, Second Affiliated Hospital, Zhejiang University, Hangzhou, Zhejiang, China.


Locoregional therapy is playing an increasingly important role in the non-surgical management of hepatocellular carcinoma (HCC). The novel technique of non-thermal electric ablation by nanosecond pulsed electric field has been recognized as a potential locoregional methodology for indicated HCC. This manuscript explores the most recent studies to indicate its unique anti-tumor immune response. The possible immune mechanism, termed as nano-pulse stimulation, was also analyzed.


Hepatocellular carcinoma (HCC); Locoregional therapy; Nano-pulse stimulation (NPS); Nanosecond pulsed electric field (nsPEF)

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The authors have no conflict of interests related to this publication.

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