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J Clin Transl Hepatol. 2018 Mar 28;6(1):85-88. doi: 10.14218/JCTH.2017.00042. Epub 2017 Oct 27.

Activation of Anti-tumor Immune Response by Ablation of HCC with Nanosecond Pulsed Electric Field.

Author information

1
Collaborative Innovation Center for Diagnosis Treatment of Infectious Diseases, Key Laboratory of Combined Multi-organ Transplantation, Ministry of Public Health, Department of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital, Zhejiang University, Hangzhou, Zhejiang, China.
2
Department of Anatomy, Tianjin Medical University, Tianjin, China.
3
Hepatobiliary & Hydatid Department, Digestive and Vascular Surgery Centre, Xinjiang Key Laboratory of Echinococcosis, First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.
4
Department of Orthopedics, Second Affiliated Hospital, Zhejiang University, Hangzhou, Zhejiang, China.

Abstract

Locoregional therapy is playing an increasingly important role in the non-surgical management of hepatocellular carcinoma (HCC). The novel technique of non-thermal electric ablation by nanosecond pulsed electric field has been recognized as a potential locoregional methodology for indicated HCC. This manuscript explores the most recent studies to indicate its unique anti-tumor immune response. The possible immune mechanism, termed as nano-pulse stimulation, was also analyzed.

KEYWORDS:

Hepatocellular carcinoma (HCC); Locoregional therapy; Nano-pulse stimulation (NPS); Nanosecond pulsed electric field (nsPEF)

Conflict of interest statement

The authors have no conflict of interests related to this publication.

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