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Evid Based Complement Alternat Med. 2018 Jan 17;2018:7827565. doi: 10.1155/2018/7827565. eCollection 2018.

Advanced Effect of Moringa oleifera Bioconversion by Rhizopus oligosporus on the Treatment of Atopic Dermatitis: Preliminary Study.

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Division of Integrated Biotechnology, Joongbu University, Chungnam 32713, Republic of Korea.
Factorial Research Center, Inc., Seoul 06103, Republic of Korea.
Laboratory of Animal Medicine, College of Veterinary Medicine, Chonnam National University, Gwangju 61186, Republic of Korea.


This study was conducted to determine if topical application of Moringa oleifera extracts and its bioconversion product fermented by Rhizopus oligosporus has therapeutic properties enhancement for treatment of atopic dermatitis. Rhizopus oligosporus (KCCM 11232P) was used to ferment Moringa leaves' extracts in this study. Comparison of organic acids and flavonols in Moringa simple extracts and their fermented product by HPLC analysis revealed that concentration of organic acids and flavonols of bioconversion product was lower than that of hot water extracts. The fermentation process is used as a nutrient for isolation of each component by microorganisms and growth of microorganisms. The results demonstrated that MF extracts effectively reduced clinical features based on macrography, scratching count, and severity scores, as well as model's serum IgE level, including histopathological analyses.

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