Format

Send to

Choose Destination
Clin Nutr ESPEN. 2018 Apr;24:54-57. doi: 10.1016/j.clnesp.2018.01.070. Epub 2018 Feb 23.

Hyperlipidemia secondary to acitretin therapy for lamellar ichthyosis associated with a NIPAL4 mutation improves on a plant-based diet and relapses on a standard Western diet.

Author information

1
Albert Einstein College of Medicine, Bronx, NY 10461, USA. Electronic address: jlin5@mail.einstein.yu.edu.
2
Department of Medicine, Division of Cardiology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY 10467, USA. Electronic address: dmassera@montefiore.org.
3
Department of Medicine, Division of Oncology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY 10467, USA. Electronic address: mhghalib@montefiore.org.
4
Division of Genetic Medicine, Department of Pediatrics, Children's Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, NY 10467, USA. Electronic address: rmarion@montefiore.org.
5
Department of Clinical Nutrition, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY 10467, USA. Electronic address: lgraf@montefiore.org.
6
Division of Dermatology, Albert Einstein College of Medicine, Bronx, NY 10461, USA. Electronic address: srcohen@montefiore.org.
7
Department of Medicine, Division of Cardiology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY 10467, USA. Electronic address: rostfeld@montefiore.org.

Abstract

Oral retinoids are commonly prescribed for many dermatological conditions and may induce hyperlipidemia. We document the case of a 35-year-old man taking acitretin for congenital lamellar ichthyosis associated with a homozygous deleterious mutation in NIPAL4 who developed retinoid-induced hyperlipidemia that responded dramatically to a whole-food plant-based (WFPB) diet. On presentation, his diet consisted of chicken, fish, low fat meats and dairy, grains, and some fruits and vegetables. He then adopted a WFPB diet without making changes to his medications. His serum lipid levels dropped and his exercise capacity improved. Five months later, after discontinuing the plant-based diet and returning to his baseline diet, his hyperlipidemia returned and persisted despite adjustments to his medications. After a year and a half, the patient again adopted a plant-based diet and his lipid levels fell sharply again. A WFPB diet helped improve and control serum lipid levels in a patient with retinoid-induced hyperlipidemia. Future interventions should focus on ways to help patients successfully adopt and maintain a WFPB diet, as increased adherence to a healthy lifestyle is associated with greater health benefits.

KEYWORDS:

Acitretin; Congenital ichthyosis; Hyperlipidemia; Plant-based diet

PMID:
29576363
DOI:
10.1016/j.clnesp.2018.01.070
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center