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Scand J Public Health. 2018 Aug;46(6):630-637. doi: 10.1177/1403494818764782. Epub 2018 Mar 26.

Geographic origin as a determinant of left ventricular mass and diastolic function - the Cardiovascular Risk in Young Finns Study.

Author information

1
1 Research Center of Applied and Preventive Cardiovascular Medicine, University of Turku, Finland.
2
2 Department of Medicine, University of Turku and Division of Medicine, Turku University Hospital, Finland.
3
3 Department of Pediatrics, University of Tampere and Tampere University Hospital, Finland.
4
4 Department of Clinical Physiology, Tampere University Hospital and University of Tampere, Finland.
5
5 Department of Clinical Physiology and Nuclear Medicine, University of Eastern Finland and Kuopio University Hospital, Finland.
6
6 Department of Pediatrics, University of Oulu, Finland.
7
7 Department of Pediatric Cardiology, Hospital for Children and Adolescents, University of Helsinki, Finland.
8
8 Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Finland.
9
9 Paavo Nurmi Centre, Sports and Exercise Medicine Unit, Department of Physical Activity and Health, University of Turku, Finland.

Abstract

AIMS:

Eastern Finns have higher risk of coronary heart disease (CHD) and carotid intima-media thickness than western Finns although current differences in CHD risk factors are minimal. Left ventricular (LV) mass and diastolic function predict future cardiovascular events but their east-west differences are unknown. We examined the association of eastern/western baseline origin with LV mass and diastolic function.

METHODS:

The study population included 2045 subjects of the Cardiovascular Risk in Young Finns Study with data from the baseline survey (1980) and the latest follow-up (2011) when echocardiography was performed at the age of 34-49 years.

RESULTS:

Subjects with eastern baseline origin had in 2011 higher LV mass (139±1.0 vs. 135±1.0 g, p=0.006) and E/e'-ratio indicating weaker LV diastolic function (4.86±0.03 vs. 4.74±0.03, p=0.02) than western subjects. Results were independent of age, sex, area of examination and CHD risk factors such as blood pressure and BMI (LV mass indexed with height: p<0.0001; E/e'-ratio: p=0.01). LV end-diastolic volume was higher among subjects with eastern baseline origin (135±0.9 vs. 131±0.9 ml, p=0.0011) but left atrial end-systolic volume, also indicating LV diastolic function, was not different between eastern and western subjects (43.4±0.5 vs. 44.0±0.5 ml, p=0.45). Most of the subjects were well within the normal limits of these echocardiographic measurements.

CONCLUSIONS:

In our healthy middle-aged population, geographic origin in eastern Finland associated with higher LV mass compared to western Finland. Higher E/e'-ratio suggests that subjects with eastern baseline origin might have higher prevalence of diastolic dysfunction in the future than western subjects.

KEYWORDS:

Atherosclerosis; Echocardiography; Population; Risk Factors

PMID:
29576010
DOI:
10.1177/1403494818764782
[Indexed for MEDLINE]

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