Format

Send to

Choose Destination
Aging Cell. 2018 Jun;17(3):e12746. doi: 10.1111/acel.12746. Epub 2018 Mar 25.

The effects of graded caloric restriction: XII. Comparison of mouse to human impact on cellular senescence in the colon.

Author information

1
Division of Geriatrics and Nutritional Sciences and Center for Human Nutrition, Washington University School of Medicine, St. Louis, MO, USA.
2
Department of Clinical and Experimental Sciences, Brescia University, Brescia, Italy.
3
Institute of Biological and Environmental Sciences, University of Aberdeen, Aberdeen, UK.
4
European Research Institute for the Biology of Aging, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
5
State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China.

Abstract

Calorie restriction (CR) is an effective strategy to delay the onset and progression of aging phenotypes in a variety of organisms. Several molecular players are involved in the anti-aging effects of CR, but mechanisms of regulation are poorly understood. Cellular senescence-a cellular state of irreversible growth arrest-is considered a basic mechanism of aging. Senescent cells accumulate with age and promote a number of age-related pathologies. Whether environmental conditions such as diet affect the accumulation of cellular senescence with age is still unclear. Here, we show that a number of classical transcriptomic markers of senescent cells are reduced in adult but relatively young mice under CR. Moreover, we demonstrate that such senescence markers are not induced in the colon of middle-age human volunteers under CR in comparison with age-matched volunteers consuming normal Western diets. Our data support the idea that the improvement in health span observed in different organisms under CR might be partly due to a reduction in the number of senescent cells.

KEYWORDS:

SASP; ageing; aging; caloric restriction; cellular senescence

PMID:
29575469
PMCID:
PMC5946078
DOI:
10.1111/acel.12746
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Wiley Icon for PubMed Central
Loading ...
Support Center