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J Korean Med Sci. 2018 Mar 26;33(13):e96. doi: 10.3346/jkms.2018.33.e96.

Non-Motor Symptom Burdens Are Not Associated with Iron Accumulation in Early Parkinson's Disease: a Quantitative Susceptibility Mapping Study.

Author information

1
Department of Neurology, Kyung Hee University Medical Center, Seoul, Korea.
2
Department of Mechanical and Aerospace Engineering, Seoul National University, Seoul, Korea.
3
Department of Neurology, Seoul National University-Seoul Metropolitan Government Boramae Medical Center, Seoul, Korea.
4
Department of Radiology, Seoul National University-Seoul Metropolitan Government Boramae Medical Center, Seoul, Korea.
5
Department of Radiology, Seoul National University College of Medicine, Seoul, Korea. swpark8802@gmail.com.

Abstract

BACKGROUND:

Quantitative susceptibility mapping (QSM) has been used to measure iron accumulation in the deep nuclei of patients with Parkinson's disease (PD). This study examined the relationship between non-motor symptoms (NMSs) and iron accumulation in the deep nuclei of patients with PD.

METHODS:

The QSM data were acquired from 3-Tesla magnetic resonance imaging (MRI) in 29 patients with early PD and 19 normal controls. The Korean version of the NMS scale (K-NMSS) was used for evaluation of NMSs in patients. The patients were divided into high NMS and low NMS groups. The region-of-interest analyses were performed in the following deep nuclei: red nucleus, substantia nigra pars compacta, substantia nigra pars reticulata, dentate nucleus, globus pallidus, putamen, and head of the caudate nucleus.

RESULTS:

Thirteen patients had high NMS scores (total K-NMSS score, mean = 32.1), and 16 had low NMS scores (10.6). The QSM values in the deep were not different among the patients with high NMS scores, low NMS scores, and controls. The QSM values were not correlated linearly with K-NMSS total score after adjusting the age at acquisition of brain MRI.

CONCLUSION:

The study demonstrated that the NMS burdens are not associated with iron accumulation in the deep nuclei of patients with PD. These results suggest that future neuroimaging studies on the pathology of NMSs in PD should use more specific and detailed clinical tools and recruit PD patients with severe NMSs.

KEYWORDS:

Basal Ganglia; Iron; Magnetic Resonance Imaging; Parkinson Disease

PMID:
29573246
PMCID:
PMC5865060
DOI:
10.3346/jkms.2018.33.e96
[Indexed for MEDLINE]
Free PMC Article

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