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Hum Brain Mapp. 2018 Jul;39(7):2917-2928. doi: 10.1002/hbm.24049. Epub 2018 Mar 24.

Meta-analytic evidence for altered mesolimbic responses to reward in schizophrenia.

Author information

1
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
2
Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Aachen, Germany.
3
Juelich Aachen Research Alliance - Translational Brain Medicine, Aachen, Germany.
4
Institute of Neuroscience and Medicine, Brain and Behaviour (INM-7), Research Center Jülich, Jülich, Germany.
5
Institute for Systems Neuroscience, Medical Faculty, Heinrich-Heine University Düsseldorf, Düsseldorf, Germany.
6
Iowa Neuroscience Institute, University of Iowa, Iowa City, IA, USA.
7
Department of Psychiatry, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.

Abstract

Dysfunction of reward-related neural circuitry in schizophrenia (SCZ) has been widely reported, and may provide insight into the motivational and cognitive disturbances that characterize the disorder. Although previous meta-analyses of reward learning paradigms in SCZ have been performed, a meta-analysis of whole-brain coordinate maps in SCZ alone has not been conducted. In this study, we performed an activation likelihood estimate (ALE) meta-analysis, and performed a follow-up analysis of functional connectivity and functional decoding of identified regions. We report several salient findings that extend prior work in this area. First, an alteration in reward-related activation was observed in the right ventral striatum, but this was not solely driven by hypoactivation in the SCZ group compared to healthy controls. Second, the region was characterized by functional connectivity primarily with the lateral prefrontal cortex and pre-supplementary motor area (preSMA), as well as subcortical regions such as the thalamus which show structural deficits in SCZ. Finally, although the meta-analysis showed no regions outside the ventral striatum to be significantly altered, regions with higher functional connectivity with the ventral striatum showed a greater number of subthreshold foci. Together, these findings confirm the alteration of ventral striatal function in SCZ, but suggest that a network-based approach may assist future analysis of the functional underpinnings of the disorder.

KEYWORDS:

functional magnetic resonance imaging; meta-analysis; reward; schizophrenia

PMID:
29573046
DOI:
10.1002/hbm.24049

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