Format

Send to

Choose Destination
Matrix Biol. 2018 Aug;68-69:67-80. doi: 10.1016/j.matbio.2018.03.017. Epub 2018 Mar 20.

The WNT signaling pathways in wound healing and fibrosis.

Author information

1
Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado Denver, Aurora, CO, USA.
2
Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado Denver, Aurora, CO, USA. Electronic address: melanie.koenigshoff@ucdenver.edu.

Abstract

The WNT signaling pathways are major regulators of organ development. Ample research over the past few decades revealed that these pathways are critically involved in adult tissue homeostasis and stem cell function as well as the development of chronic diseases, such as cancer and fibrosis. In this review, we will describe the different WNT signal pathways, summarize the current evidence of WNT signal involvement in wound healing and fibrosis, and highlight potential novel therapeutic options for fibrotic disorders targeting WNT signaling pathways.

KEYWORDS:

Cell reprogramming; Fibrosis; Repair; Tissue regeneration; WNT signaling

PMID:
29572156
DOI:
10.1016/j.matbio.2018.03.017
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center