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J Clin Neurosci. 2018 Jun;52:105-108. doi: 10.1016/j.jocn.2018.01.046. Epub 2018 Mar 21.

Modification of apparent intracerebral hematoma volume on T2-weighted images during normobaric oxygen therapy may contribute to false diagnosis.

Author information

1
INSERM, UMR-S U1237, Pathophysiology and Imaging of Neurological Disorders, University Caen-Normandy, CHU Caen, GIP Cyceron, Bd Henri Becquerel, Caen, France.
2
INSERM, UMR-S U1237, Pathophysiology and Imaging of Neurological Disorders, University Caen-Normandy, CHU Caen, GIP Cyceron, Bd Henri Becquerel, Caen, France; Department of Neurosurgery, Caen University Hospital, Avenue de la côte de Nacre, Caen, France.
3
UMS 3408, UNICAEN, CNRS, GIP Cyceron, Bd Henri Becquerel, Caen, France.
4
UMR6301-ISTCT, CNRS, CERVOxy Group, GIP Cyceron, Bd Henri Becquerel, Caen, France.
5
INSERM, UMR-S U1237, Pathophysiology and Imaging of Neurological Disorders, University Caen-Normandy, CHU Caen, GIP Cyceron, Bd Henri Becquerel, Caen, France; Department of Anesthesiology and Critical Care Medicine, Caen University Hospital, Avenue de la côte de Nacre, Caen, France.
6
INSERM, UMR-S U1237, Pathophysiology and Imaging of Neurological Disorders, University Caen-Normandy, CHU Caen, GIP Cyceron, Bd Henri Becquerel, Caen, France; Department of Radiology, Caen University Hospital, Avenue de la cote de Nacre, Caen, France.
7
INSERM, UMR-S U1237, Pathophysiology and Imaging of Neurological Disorders, University Caen-Normandy, CHU Caen, GIP Cyceron, Bd Henri Becquerel, Caen, France; UMR6301-ISTCT, CNRS, CERVOxy Group, GIP Cyceron, Bd Henri Becquerel, Caen, France. Electronic address: vivien@cyceron.fr.

Abstract

It was previously reported that normobaric oxygen therapy (NBO) significantly affected T2-weighted imaging in a mouse model of intracerebral hemorrhage (ICH). However, it is unclear whether a similar phenomenon exists in large volume ICH as seen in human pathology. We investigated the effects of NBO on T2-weighted images in a pig model of ICH. Our data show that NBO makes disappear a peripheral crown of the hematoma, which in turn decreases the apparent volume of ICH by 18%. We hypothesized that this result could be translated to ICH in human, and subsequently could lead to inaccurate diagnostic.

KEYWORDS:

Diagnostic errors; Intracerebral hemorrhage; Magnetic resonance imaging; Oxygen inhalation therapy

PMID:
29571939
DOI:
10.1016/j.jocn.2018.01.046
[Indexed for MEDLINE]

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