Format

Send to

Choose Destination
Clin Pharmacol Ther. 2018 Jul;104(1):23-26. doi: 10.1002/cpt.1051. Epub 2018 Mar 23.

Patient Enrichment for Precision-Based Cancer Clinical Trials: Using Prospective Cohort Surveillance as an Approach to Improve Clinical Trials.

Author information

1
M2Gen Inc, Tampa, Florida, USA.
2
Clinical Science, H. Lee Moffitt Cancer Center, Tampa, Florida, USA.
3
Translational Medicine, Takeda Pharmaceuticals International Co, Cambridge, Massachusetts, USA.
4
Ohio State University Comprehensive Cancer Center; The James Cancer Hospital and Solove Research Institute, Ohio State University, Columbus, Ohio, USA.

Abstract

Technological advances have led to the identification of biomarkers and development of novel target-based therapies. While some novel therapies have improved patient outcomes, the prevalence and diversity of biomarkers and targets in patient populations, especially patients with cancer, has created a challenge for the design and performance of clinical trials. To address this challenge we propose that prospective cohort surveillance of patients may be a solution to promote clinical trial matching for patients in need.

PMID:
29570791
PMCID:
PMC6032821
DOI:
10.1002/cpt.1051
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Wiley Icon for PubMed Central
Loading ...
Support Center