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F1000Res. 2018 Mar 2;7:260. doi: 10.12688/f1000research.13426.1. eCollection 2018.

NFAT control of immune function: New Frontiers for an Abiding Trooper.

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1
Department of Pathology, New York University School of Medicine, New York, NY, 10016, USA.

Abstract

Nuclear factor of activated T cells (NFAT) was first described almost three decades ago as a Ca 2+/calcineurin-regulated transcription factor in T cells. Since then, a large body of research uncovered the regulation and physiological function of different NFAT homologues in the immune system and many other tissues. In this review, we will discuss novel roles of NFAT in T cells, focusing mainly on its function in humoral immune responses, immunological tolerance, and the regulation of immune metabolism.

KEYWORDS:

CRAC; Calcium; NFAT; STIM; T cell; anergy; exhaustion; metabolism

Conflict of interest statement

Competing interests: SF is a co-founder of CalciMedica. MV declares that he has no competing interests.No competing interests were disclosed.No competing interests were disclosed.

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