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Cell Mol Immunol. 2018 Dec;15(12):1003-1009. doi: 10.1038/s41423-018-0007-1. Epub 2018 Mar 22.

Role of Hippo signaling in regulating immunity.

Author information

1
State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Biology, School of Life Sciences, Xiamen University, Fujian, 361102, Xiamen, China.
2
Department of Laboratory Medicine, The First Affiliated Hospital, Medical College of Xiamen University, Fujian, 361003, Xiamen, China.
3
State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Biology, School of Life Sciences, Xiamen University, Fujian, 361102, Xiamen, China. chenlanfen@xmu.edu.cn.

Abstract

The Hippo signaling pathway has been established as a key regulator of organ size control, tumor suppression, and tissue regeneration in multiple organisms. Recently, emerging evidence has indicated that Hippo signaling might play an important role in regulating the immune system in both Drosophila and mammals. In particular, patients bearing a loss-of-function mutation of MST1 are reported to have an autosomal recessive primary immunodeficiency syndrome. MST1/2 kinases, the mammalian orthologs of Drosophila Hippo, may activate the non-canonical Hippo signaling pathway via MOB1A/B and/or NDR1/2 or cross-talk with other essential signaling pathways to regulate both innate and adaptive immunity. In this review, we present and discuss recent findings of cellular mechanisms/functions of Hippo signaling in the innate immunity in Drosophila and in mammals, T cell immunity, as well as the implications of Hippo signaling for tumor immunity.

KEYWORDS:

MST1/2; The Hippo pathway; adaptive immunity; innate immunity

PMID:
29568120
PMCID:
PMC6269503
DOI:
10.1038/s41423-018-0007-1
[Indexed for MEDLINE]
Free PMC Article

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