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Dev Cogn Neurosci. 2018 Apr;30:191-199. doi: 10.1016/j.dcn.2018.03.006. Epub 2018 Mar 13.

Interaction between striatal volume and DAT1 polymorphism predicts working memory development during adolescence.

Author information

1
Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden. Electronic address: federico.nemmi@ki.se.
2
Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden.
3
Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
4
Discipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin, Ireland.
5
University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.
6
Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany; Department of Psychology, School of Social Sciences, University of Mannheim, Mannheim, Germany.
7
NeuroSpin, CEA, Université Paris-Saclay, Gif-sur-Yvette, France.
8
Departments of Psychiatry and Psychology, University of Vermont, Burlington, VT, USA.
9
Sir Peter Mansfield Imaging Centre School of Physics and Astronomy, University of Nottingham,University Park, Nottingham, United Kingdom.
10
Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité, Universitätsmedizin Berlin, Berlin, Germany.
11
Institut National de la Santé et de la Recherche Médicale, INSERM Unit 1000 "Neuroimaging & Psychiatry", University Paris Sud - Paris Saclay, University Paris Descartes, Service Hospitalier Frédéric Joliot, Orsay; and Maison de Solenn, Paris, France.
12
Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany; Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
13
Rotman Research Institute, Baycrest and Departments of Psychology and Psychiatry, University of Toronto, Toronto, Ontario, Canada.
14
Department of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, Germany.
15
Department of Psychology, Behavioral and Clinical Neuroscience Institute, University of Cambridge, Cambridge, United Kingdom.
16
Medical Research Council - Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, United Kingdom.

Abstract

There is considerable inter-individual variability in the rate at which working memory (WM) develops during childhood and adolescence, but the neural and genetic basis for these differences are poorly understood. Dopamine-related genes, striatal activation and morphology have been associated with increased WM capacity after training. Here we tested the hypothesis that these factors would also explain some of the inter-individual differences in the rate of WM development. We measured WM performance in 487 healthy subjects twice: at age 14 and 19. At age 14 subjects underwent a structural MRI scan, and genotyping of five single nucleotide polymorphisms (SNPs) in or close to the dopamine genes DRD2, DAT-1 and COMT, which have previously been associated with gains in WM after WM training. We then analyzed which biological factors predicted the rate of increase in WM between ages 14 and 19. We found a significant interaction between putamen size and DAT1/SLC6A3 rs40184 polymorphism, such that TC heterozygotes with a larger putamen at age 14 showed greater WM improvement at age 19. The effect of the DAT1 polymorphism on WM development was exerted in interaction with striatal morphology. These results suggest that development of WM partially share neuro-physiological mechanism with training-induced plasticity.

KEYWORDS:

DAT-1; Development; Dopamine; Striatum; Working memory; rs40184

PMID:
29567584
DOI:
10.1016/j.dcn.2018.03.006
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