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Curr Transplant Rep. 2018;5(1):72-81. doi: 10.1007/s40472-018-0178-9. Epub 2018 Jan 20.

From "Gut Feeling" to Objectivity: Machine Preservation of the Liver as a Tool to Assess Organ Viability.

Author information

1
1Department of Surgery, University of Cambridge School of Clinical Medicine, Cambridge, UK.
2
2The National Institute of Health Research (NIHR) Cambridge Biomedical Research Centre and the NIHR Blood and Transplant Research Unit (BTRU) at the University of Cambridge in collaboration with Newcastle University and in partnership with NHS Blood and Transplant (NHSBT), Cambridge, UK.
3
3Laboratory of Abdominal Transplant Surgery, Department of Microbiology and Immunology, KU Leuven, Leuven, Belgium.
4
4Department of Abdominal Transplant Surgery, University Hospitals Leuven, Leuven, Belgium.

Abstract

Purpose of Review:

The purpose of this review was to summarise how machine perfusion could contribute to viability assessment of donor livers.

Recent Findings:

In both hypothermic and normothermic machine perfusion, perfusate transaminase measurement has allowed pretransplant assessment of hepatocellular damage. Hypothermic perfusion permits transplantation of marginal grafts but as yet has not permitted formal viability assessment. Livers undergoing normothermic perfusion have been investigated using parameters similar to those used to evaluate the liver in vivo. Lactate clearance, glucose evolution and pH regulation during normothermic perfusion seem promising measures of viability. In addition, bile chemistry might inform on cholangiocyte viability and the likelihood of post-transplant cholangiopathy.

Summary:

While the use of machine perfusion technology has the potential to reduce and even remove uncertainty regarding liver graft viability, analysis of large datasets, such as those derived from large multicenter trials of machine perfusion, are needed to provide sufficient information to enable viability parameters to be defined and validated .

KEYWORDS:

Liver transplantation; Machine perfusion; Normothermic perfusion; Organ preservation; Viability assessment

Conflict of interest statement

Compliance with Ethical StandardsIna Jochmans reports non-financial support from Astellas Pharma (for travel, accommodation and registration for conferences) and received speaker fees paid to institution from Sanofi Genzyme, outside the submitted work.This article does not contain any studies with human or animal subjects performed by any of the authors.

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