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Asian J Transfus Sci. 2018 Jan-Jun;12(1):89-92. doi: 10.4103/ajts.AJTS_119_16.

Detection of antibodies to co-trimoxazole (preservative drug) interfering with routine red cell antibody screening.

Author information

1
Department of Transfusion Medicine, Global Health City, Chennai, Tamil Nadu, India.

Abstract

Drug-dependent antibodies can rarely cause interference in pretransfusion antibody screening. The diluents for commercial reagent red blood cells contain different antibiotics, such as chloramphenicol, neomycin sulfate, and gentamycin as a preservative. The presence of antibodies to a given drug in patient may lead to positive results when performing antibody identification. We present a rare case of detection of anti-co-trimoxazole antibody during routine antibody screening in a female patient undergoing neurosurgery. These antibodies mimicked as antibody against high-frequency red cell antigens reacting in both saline phase as well as antiglobulin phase. Anti-co-trimoxazole antibody was confirmed by repeating antibody screen using reagent red cells of different manufacturers with and without co-trimoxazole drug as preservative as well as using washed red cell panels. There were no associated clinical or laboratory evidence of hemolysis.

KEYWORDS:

Antibody identification; drug-induced antibodies; high-frequency antigen; preservative; red cell reagents

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