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Br J Cancer. 2018 May;118(9):1248-1254. doi: 10.1038/s41416-018-0055-4. Epub 2018 Mar 22.

Fasting blood glucose, glycaemic control and prostate cancer risk in the Finnish Randomized Study of Screening for Prostate Cancer.

Author information

1
Faculty of Medicine and life Sciences, University of Tampere, Tampere, Finland. teemu.murtola@uta.fi.
2
Department of Urology, Tampere University Hospital, Tampere, Finland. teemu.murtola@uta.fi.
3
Faculty of Medicine and life Sciences, University of Tampere, Tampere, Finland.
4
Department of Internal Medicine, Tampere University Hospital, Tampere, Finland.
5
Finnish Cancer Registry, Helsinki, Finland.
6
Department of Urology, Helsinki University and Helsinki University Hospital, Helsinki, Finland.
7
Department of Urology, Tampere University Hospital, Tampere, Finland.
8
Faculty of Social Sciences, University of Tampere, Tampere, Finland.

Abstract

BACKGROUND:

Diabetic men have lowered overall risk of prostate cancer (PCa), but the role of hyperglycaemia is unclear. In this cohort study, we estimated PCa risk among men with diabetic fasting blood glucose level.

METHODS:

Participants of the Finnish Randomized Study of Screening for Prostate Cancer (FinRSPC) were linked to laboratory database for information on glucose measurements since 1978. The data were available for 17,860 men. Based on the average yearly level, the men were categorised as normoglycaemic, prediabetic, or diabetic. Median follow-up was 14.7 years. Multivariable-adjusted Cox regression was used to calculate hazard ratios (HRs) and 95% confidence intervals (95% CIs) for prostate cancer overall and separately by Gleason grade and metastatic stage.

RESULTS:

In total 1,663 PCa cases were diagnosed. Compared to normoglycaemic men, those men with diabetic blood glucose level had increased risk of PCa (HR 1.52; 95% CI 1.31-1.75). The risk increase was observed for all tumour grades, and persisted for a decade afterwards. Antidiabetic drug use removed the risk association. Limitations include absence of information on lifestyle factors and limited information on BMI.

CONCLUSIONS:

Untreated diabetic fasting blood glucose level may be a prostate cancer risk factor.

PMID:
29563633
PMCID:
PMC5943324
[Available on 2019-05-01]
DOI:
10.1038/s41416-018-0055-4

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