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J Sports Sci. 2018 Oct;36(20):2327-2332. doi: 10.1080/02640414.2018.1455260. Epub 2018 Mar 21.

The AGTR2 rs11091046 (A>C) polymorphism and power athletic status in top-level Brazilian athletes.

Author information

1
a Laboratory of Applied Nutrition and Metabolism, School of Physical Education and Sport , University of Sao Paulo , Sao Paulo , Brazil.
2
b Endurance Performance Research Group, School of Physical Education and Sport , University of São Paulo , Sao Paulo , Brazil.

Abstract

The main purpose of this study was to investigate if the rs11091046 (A>C) polymorphism in AGTR2 gene is associated with athletic status in top-level athletes from Brazil. Since the AGTR2 gene is located on the X chromosome, the case-control association study was done separately for women and men. The female cohort was composed of 205 athletes and 241 non-athletes, and the male cohort was composed of 419 athletes and 490 non-athletes. We did not identify an association between the C-allele and the endurance phenotype. However, power athletes had a higher frequency of the A-allele. In women, A/A genotype was overrepresented in international-level power group compared with non-athletes or international-level endurance athletes (23.2% vs. 16.6% or 8.8%, respectively; p < 0.05). In men, the A-allele frequency observed in power athletes or international-level power athletes was statistically different from that observed in non-athletes (51.6% or 57.8% vs. 40.4%; p < 0.009). Furthermore, men sprinters with the A-allele showed significantly faster personal best times for the 100 m than those with the C-allele (10.56 ± 0.32 s vs. 10.93 ± 0.49 s; p < 0.02). In conclusion, it was found that the AGTR2 A-allele is a candidate genetic marker for top-level power athletes.

KEYWORDS:

Gene variant; Genetics; Renin–angiotensin system; Sports performance; Sprinting performance

PMID:
29561708
DOI:
10.1080/02640414.2018.1455260
[Indexed for MEDLINE]

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