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J Biomech Eng. 2018 Mar 19. doi: 10.1115/1.4039625. [Epub ahead of print]

Material properties of rat middle cerebral arteries at high strain rates.

Author information

1
Department of Bioengineering, University of Utah, Salt Lake City, UT 84112 USA.
2
Department of Mechanical Engineering, University of Utah, Salt Lake City, UT 84112 USA.
3
Department of Defense Biotechnology High Performance Computing Software Applications Institute, Telemedicine and Advanced Technology Research Center, US Army Medical Research and Materiel Command, Fort Detrick, Frederick, MD 21702 USA.
4
Department of Bioengineering, University of Utah, Salt Lake City, UT 84112 USA; Department of Mechanical Engineering, University of Utah, Salt Lake City, UT 84112 USA.

Abstract

Traumatic brain injury (TBI), resulting from either impact- or non-impact blast-related mechanisms, is a devastating cause of death and disability. The cerebral blood vessels, which provide critical support for brain tissue in both health and disease, are commonly injured in TBI. However, little is known about how vessels respond to traumatic loading, particularly at rates relevant to blast. To better understand vessel responses to trauma, the objective of this project was to characterize the high-rate response of passive cerebral arteries. Rat middle cerebral arteries were isolated and subjected to high-rate deformation in the axial direction. Vessels were perfused at physiological pressures and stretched to failure at strain rates ranging from approximately 100 to 1300 s-1. Although both in vivo stiffness and failure stress increased significantly with strain rate, failure stretch did not depend on rate.

PMID:
29560495
DOI:
10.1115/1.4039625

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