[Curative effect of ozone hydrotherapy for pemphigus]

Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2018 Feb 28;43(2):152-156. doi: 10.11817/j.issn.1672-7347.2018.02.008.
[Article in Chinese]

Abstract

To determine clinical curative effects of ozone therapy for pemphigus vulgaris. Methods: Ozone hydrotherapy was used as an aid treatment for 32 patients with pemphigus vulgaris. The hydropathic compression of potassium permanganate solution for 34 patients with pemphigus vulgaris served as a control. The main treatment for both groups were glucocorticoids and immune inhibitors. The lesions of patients, bacterial infection, usage of antibiotics, patient's satisfaction, and clinical curative effect were evaluated in the 2 groups. Results: There was no significant difference in the curative effect and the average length of staying at hospital between the 2 groups (P>0.05). But rate for the usage of antibiotics was significantly reduced in the group of ozone hydrotherapy (P=0.039). The patients were more satisfied in using ozone hydrotherapy than the potassium permanganate solution after 7-day therapy (P>0.05). Conclusion: Ozone hydrotherapy is a safe and effective aid method for pemphigus vulgaris. It can reduce the usage of antibiotics.

目的:观察臭氧水疗辅助治疗寻常型天疱疮患者的疗效。方法:32例住院治疗的寻常型天疱疮患者使用臭氧水疗作为皮疹的辅助治疗;同期住院治疗的34例寻常型天疱疮患者采用高锰酸钾溶液湿敷或泡澡作为对照。两组患者治疗中均使用激素及免疫抑制药作为主要的治疗手段。观察患者住院期间皮疹好转情况,皮疹处细菌感染情况及抗生素的使用率,评价患者满意度,对两组疗效进行比较。结果:臭氧水疗组与对照组的疗效及平均住院日差异无统计学意义(P>0.05);但住院期间臭氧水疗组抗生素使用率较对照组显著减少(P=0.039),治疗第7天患者对臭氧水疗的满意度明显高于对照组(P>0.05)。结论:臭氧水疗是天疱疮安全有效的辅助治疗手段,可以减少抗生素的使用率。.

MeSH terms

  • Anti-Bacterial Agents / therapeutic use
  • Case-Control Studies
  • Dermatologic Agents / therapeutic use*
  • Glucocorticoids
  • Humans
  • Hydrotherapy / methods*
  • Length of Stay
  • Ozone / therapeutic use*
  • Pemphigus / therapy*
  • Potassium Permanganate / therapeutic use
  • Treatment Outcome

Substances

  • Anti-Bacterial Agents
  • Dermatologic Agents
  • Glucocorticoids
  • Potassium Permanganate
  • Ozone