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Diabetes Care. 2018 Apr;41(4):653-661. doi: 10.2337/dc17-0806.

Type 1 Diabetes TrialNet: A Multifaceted Approach to Bringing Disease-Modifying Therapy to Clinical Use in Type 1 Diabetes.

Author information

1
Diabetes and Metabolism, Bristol Medical School, University of Bristol, Bristol, U.K.
2
Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Canada.
3
Diabetes Research Program, Benaroya Research Institute, Seattle, WA.
4
University of Miami Diabetes Research Institute, Miami, FL.
5
Departments of Pathology and Pediatrics, University of Florida College of Medicine,Gainesville, FL.
6
Diabetes Research Program, Benaroya Research Institute, Seattle, WA cjgreen@benaroyaresearch.org.

Abstract

What will it take to bring disease-modifying therapy to clinical use in type 1 diabetes? Coordinated efforts of investigators involved in discovery, translational, and clinical research operating in partnership with funders and industry and in sync with regulatory agencies are needed. This Perspective describes one such effort, Type 1 Diabetes TrialNet, a National Institutes of Health-funded and JDRF-supported international clinical trials network that emerged from the Diabetes Prevention Trial-Type 1 (DPT-1). Through longitudinal natural history studies, as well as trials before and after clinical onset of disease combined with mechanistic and ancillary investigations to enhance scientific understanding and translation to clinical use, TrialNet is working to bring disease-modifying therapies to individuals with type 1 diabetes. Moreover, TrialNet uses its expertise and experience in clinical studies to increase efficiencies in the conduct of trials and to reduce the burden of participation on individuals and families. Herein, we highlight key contributions made by TrialNet toward a revised understanding of the natural history of disease and approaches to alter disease course and outline the consortium's plans for the future.

PMID:
29559451
PMCID:
PMC5860837
[Available on 2019-04-01]
DOI:
10.2337/dc17-0806
[Indexed for MEDLINE]

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