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Expert Opin Ther Pat. 2018 May;28(5):415-427. doi: 10.1080/13543776.2018.1455829. Epub 2018 Apr 3.

Bioactivity and pharmacological properties of α-mangostin from the mangosteen fruit: a review.

Author information

1
a Department of Chemistry and Chemical Engineering , Shaoxing University , Shaoxing , P.R.China.
2
b Shaoxing University Yuanpei College , Shaoxing University , Shaoxing , P.R.China.

Abstract

INTRODUCTION:

α-Mangostin (α-MG) is the most representative xanthone isolated from the pericarp of mangosteen, possessing extensive biological activities and pharmacological properties, considered as an antineoplastic agent, antioxidant, anti-proliferation and induces apoptosis.

AREAS COVERED:

The bioactivity and pharmacological properties of α-MG are being actively investigated by various industrial and academic institutions. The bioactivities of α-MG have been summarized in several previous reviews, which were worthy of high compliment. However, recently, many new literatures about the bioactivities of α-MG have been further reported from 2016 to 2017. Herein, the activities of α-MG are supplemented and summarized in this text.

EXPERT OPINION:

As previously said, α-MG possesses good bioactivities pharmacological properties. More recently, it found that α-MG has the effect of maintaining cardiovascular system and gastrointestinal health and controlling free radical oxidation. Furthermore, α-MG has more applications in cosmetics, with the effects of anti-aging, anti-wrinkle, acne treatment, maintenance of skin lubrication. The application of α-MG in treating rheumatoid arthritis has been disclosed and the MG-loaded self-micro emulsion (MG-SME) was designed to improve its pharmacokinetic deficiencies. As mentioned above, α-MG can be a promising drug, also worthy of developing, and further research is crucial for the future application of α-MG.

KEYWORDS:

biological activities; chemopreventive; pharmacology; Α-Mangostin

PMID:
29558225
DOI:
10.1080/13543776.2018.1455829
[Indexed for MEDLINE]

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