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Sci Rep. 2018 Mar 19;8(1):4788. doi: 10.1038/s41598-018-23192-x.

Waist circumference is a mediator of dietary pattern in Non-alcoholic fatty liver disease.

Author information

1
Department of Basic Sciences and Nutrition, Health Sciences Research Center, Faculty of public Health, Mazandaran University of Medical Sciences, Sari, Iran.
2
Student Research Committee, Fasa University of Medical Sciences, Fasa, Iran.
3
National Nutrition and Food Technology Research Institute, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
4
Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran.
5
Health Policy Research Center, Institute of Health, Shiraz University of Medical Science, Shiraz, Iran.
6
Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran. r_homayounfar@yahoo.com.
7
Health Policy Research Center, Institute of Health, Shiraz University of Medical Science, Shiraz, Iran. r_homayounfar@yahoo.com.

Abstract

Non-alcoholic fatty liver disease (NAFLD) is an example of pathological fat accumulation in the liver and one of the major health conditions in the world. This study aimed to examine the independent role of dietary patterns in the development of NAFLD. In a cross-sectional study, 1500 individuals referred to a nutrition clinic were randomly selected, their demographic, anthropometric and blood metabolic indices were obtained, and food frequency questionnaires were completed for them. Liver stiffness was calculated using the NAFLD score formula and fibroscan. The two dominant dietary patterns identified were the "healthy" and "unhealthy dietary patterns". A significant percentage of those with NAFLD (45%) were in the upper quartile of the unhealthy model; however, only 10% had the healthy pattern (pā€‰<ā€‰0.001). In this study, 32.9 and 13.9% of the healthy and unhealthy participants were in the upper quartile of the healthy diet pattern. Also, it was shown that waist circumference is a strong mediator of dietary patterns and NAFLD relationship, and the indirect effect of diet through abdominal circumference is 28 times greater than the direct effect on NAFLD. The results suggested that healthy and unhealthy dietary patterns are respectively associated with lower- and higher-risk of NAFLD but the role of waist circumference as a mediator deserves more consideration.

PMID:
29555959
PMCID:
PMC5859081
DOI:
10.1038/s41598-018-23192-x
[Indexed for MEDLINE]
Free PMC Article

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