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Nat Commun. 2018 Mar 19;9(1):1128. doi: 10.1038/s41467-018-03333-6.

Predator-secreted sulfolipids induce defensive responses in C. elegans.

Author information

1
Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, 92037, USA.
2
Boyce Thompson Institute and Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY, 14853, USA.
3
Department of Biology and Biotechnology, Worcester Polytechnic Institute, Worcester, MA, 01605, USA.
4
Division of Biological Sciences, University of California, San Diego, La Jolla, CA, 92093, USA.
5
Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, 92037, USA. schalasani@salk.edu.
6
Division of Biological Sciences, University of California, San Diego, La Jolla, CA, 92093, USA. schalasani@salk.edu.

Abstract

Animals respond to predators by altering their behavior and physiological states, but the underlying signaling mechanisms are poorly understood. Using the interactions between Caenorhabditis elegans and its predator, Pristionchus pacificus, we show that neuronal perception by C. elegans of a predator-specific molecular signature induces instantaneous escape behavior and a prolonged reduction in oviposition. Chemical analysis revealed this predator-specific signature to consist of a class of sulfolipids, produced by a biochemical pathway required for developing predacious behavior and specifically induced by starvation. These sulfolipids are detected by four pairs of C. elegans amphid sensory neurons that act redundantly and recruit cyclic nucleotide-gated (CNG) or transient receptor potential (TRP) channels to drive both escape and reduced oviposition. Functional homology of the delineated signaling pathways and abolishment of predator-evoked C. elegans responses by the anti-anxiety drug sertraline suggests a likely conserved or convergent strategy for managing predator threats.

PMID:
29555902
PMCID:
PMC5859177
DOI:
10.1038/s41467-018-03333-6
[Indexed for MEDLINE]
Free PMC Article

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