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Biochem Cell Biol. 2018 Oct;96(5):498-506. doi: 10.1139/bcb-2018-0027. Epub 2018 Mar 19.

MicroRNAs in type 1 diabetes: new research progress and potential directions.

Author information

1
a Department of Pharmacy, College of Life and Health Science, Anhui Science and Technology University, Fengyang 233100, China.
2
b Department of Orthopaedics, 4th Affiliated Hospital, Anhui Medical University, Hefei 230032, China.
3
c College of Tea and Food Science and Technology, Anhui Agricultural University, Hefei 230036, China.

Abstract

MicroRNAs (miRNAs) are a class of noncoding single-stranded RNA molecules encoded by endogenous genes of about 22 nucleotides, which are involved in post-transcriptional gene expression regulation in animals and plants. Type 1 diabetes (T1D) is an autoimmune disease that is clinically silent until the majority of β cells are destroyed, and a large number of studies have shown that miRNAs are involved in the pathological mechanism of T1D. In this review, we searched the related research in recent years and summarized the important roles of miRNAs in T1D diagnosis and treatment. Furthermore, we summarized the current understanding of miRNA-mediated regulation mechanisms of gene expression in the T1D pathogenesis as well as related signaling pathways with a focus on the important roles of miRNAs and their antagonists in T1D pathogenesis, and brought insight into the potential therapeutic value of miRNAs for T1D patients. In view of the important roles of miRNAs in T1D pathology, disordered miRNAs may be important diagnostic markers and therapeutic targets for patients with T1D.

KEYWORDS:

autoimmune disease; cellules β; diabète de type 1; insulin; insuline; maladie auto-immune; micro-ARN; microRNA; type 1 diabetes; β cells

PMID:
29554441
DOI:
10.1139/bcb-2018-0027
[Indexed for MEDLINE]

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