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Cornea. 2018 Jun;37(6):712-719. doi: 10.1097/ICO.0000000000001575.

A Comparative Study of Central Corneal Epithelial, Stromal, and Total Thickness in Males With and Without Primary Open-Angle Glaucoma.

Author information

1
Department of Ophthalmology, Miami Veterans Administration Medical Center, Miami, FL.
2
Bascom Palmer Eye Institute, University of Miami, Miami, FL.
3
Department of Ophthalmology, King Abdul Aziz University, Jeddah, Saudi Arabia.
4
University of Miami, Miller School of Medicine, Miami, FL.
5
Center for Prevention and Treatment of Visual Loss, Iowa City Veterans Administration Medical Center, Iowa City, IA.
6
Departments of Ophthalmology and Visual Science and Molecular Physiology and Biophysics, University of Iowa, Iowa City, IA.

Abstract

PURPOSE:

To compare the central corneal epithelial thickness (CET), stromal thickness (CST), and total thickness (CCT) in males with and without primary open-angle glaucoma and to determine the factors associated with corneal thickness.

METHODS:

A case-control study was conducted to evaluate 116 male patients at the Miami Veterans Affair Medical Center. Subjects with available anterior segment optical coherence tomography images (Cirrus HD-OCT, Carl Zeiss Meditec Inc, Dublin, CA) were retrospectively classified into 2 groups by glaucoma status. CET, CST, and CCT measurements between the groups were compared. Associations between thickness and other variables of interest were also evaluated.

RESULTS:

The 2 groups were similar with respect to race and ethnicity. Mean age of patients in the glaucoma group (70.3 ± 8.9) was higher than in the nonglaucoma group (66.0 ± 11.7), P < 0.03. Individuals who self-identified as black had lower CST (447.8 ± 29.0 μm) and CCT (503.0 ± 30.5 μm) compared with whites (CST: 470.0 ± 31.7 μm; CCT: 525.1 ± 32.4 μm), P = 0.0001 and P = 0.0002, respectively. In a similar manner, individuals with glaucoma had lower CST (453.4 ± 32.5 μm) and CCT (507.3 ± 33.8 μm) than that of those without glaucoma (CST: 465.2 ± 31.2 μm; CCT: 521.5 ± 31.5 μm), P = 0.05 and P = 0.02, respectively. CET, CST, and CCT were negatively correlated with the number of antiglaucoma medications (r = -0.2, r = -0.22, and r = -0.25, respectively), P = 0.05 for all.

CONCLUSIONS:

Individuals with glaucoma have lower CST and CCT measurements compared with individuals without glaucoma. An increased number of glaucoma medications were associated with lower thickness measurements.

PMID:
29553989
PMCID:
PMC5938118
DOI:
10.1097/ICO.0000000000001575
[Indexed for MEDLINE]
Free PMC Article

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