A tumor multicomponent targeting chemoimmune drug delivery system for reprograming the tumor microenvironment and personalized cancer therapy

Samaresh Sau; Katyayani Tatiparti; Hashem O Alsaab; Sushil K Kashaw; Arun K Iyer

doi:10.1016/j.drudis.2018.03.003

A tumor multicomponent targeting chemoimmune drug delivery system for reprograming the tumor microenvironment and personalized cancer therapy

Drug Discov Today. 2018 Jul;23(7):1344-1356. doi: 10.1016/j.drudis.2018.03.003. Epub 2018 Mar 15.

Authors

Samaresh Sau¹, Katyayani Tatiparti², Hashem O Alsaab³, Sushil K Kashaw⁴, Arun K Iyer⁵

Affiliations

¹ Use-inspired Biomaterials & Integrated Nano Delivery (U-BiND) Systems Laboratory, Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI 48201, USA. Electronic address: samaresh.sau@wayne.edu.
² Use-inspired Biomaterials & Integrated Nano Delivery (U-BiND) Systems Laboratory, Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI 48201, USA.
³ Use-inspired Biomaterials & Integrated Nano Delivery (U-BiND) Systems Laboratory, Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI 48201, USA; Department of Pharmaceutics and Pharmaceutical Technology, College of Pharmacy, Taif University, Taif, Saudi Arabia.
⁴ Department of Pharmaceutical Sciences, Dr Harisingh Gour Central University, Sagar, MP 470003, India.
⁵ Use-inspired Biomaterials & Integrated Nano Delivery (U-BiND) Systems Laboratory, Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI 48201, USA; Molecular Imaging Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA. Electronic address: arun.iyer@wayne.edu.

Abstract

Nanoparticle library engineered with tunable size, shape, and geometry will provide a better idea of targeting multicomponent of tumor microenvironment consisting of epithelial cells, tumor hypoxia, tumor immune cells and angiogenic blood vessels.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Antineoplastic Agents, Immunological / adverse effects
Antineoplastic Agents, Immunological / metabolism
Antineoplastic Agents, Immunological / therapeutic use*
Clinical Decision-Making
Drug Carriers*
Drug Delivery Systems / instrumentation*
Humans
Immunoconjugates / adverse effects
Immunoconjugates / metabolism
Immunoconjugates / therapeutic use*
Nanoparticles
Neoplasms / drug therapy*
Neoplasms / immunology
Neoplasms / metabolism
Neoplasms / pathology
Neovascularization, Pathologic
Precision Medicine / methods*
Theranostic Nanomedicine / methods*
Tumor Hypoxia
Tumor Microenvironment*

Substances

Antineoplastic Agents, Immunological
Drug Carriers
Immunoconjugates

Grants and funding

R21 CA179652/CA/NCI NIH HHS/United States