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Curr Biol. 2018 Apr 2;28(7):1066-1078.e6. doi: 10.1016/j.cub.2018.02.044. Epub 2018 Mar 15.

Oxytocin Signaling in the Lateral Septum Prevents Social Fear during Lactation.

Author information

1
Department of Behavioral and Molecular Neurobiology, Regensburg Center of Neuroscience, University of Regensburg, Regensburg, Germany.
2
Schaller Research Group on Neuropeptides, German Cancer Research Center, Heidelberg, Germany.
3
Laboratory of Molecular Biology, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan.
4
Schaller Research Group on Neuropeptides, German Cancer Research Center, Heidelberg, Germany; Central Institute of Mental Health, Mannheim, Germany.
5
Department of Behavioral and Molecular Neurobiology, Regensburg Center of Neuroscience, University of Regensburg, Regensburg, Germany. Electronic address: inga.neumann@ur.de.

Abstract

Oxytocin (OXT)-mediated behavioral responses to social and stressful cues have extensively been studied in male rodents. Here, we investigated the capacity of brain OXT receptor (OXTR) signaling in the lateral septum (LS) to prevent social fear expression in female mice using the social-fear-conditioning paradigm. Utilizing the activated OXT system during lactation, we show that lactating mice did not express fear 24 hr after social fear conditioning. Supporting the role of OXTR signaling in the LS in attenuation of social fear, synthetic OXT infusion or overexpression of OXTR in the LS diminished social fear expression, whereas constitutive OXTR knockout severely impaired social fear extinction in virgin mice. Subsequently, both pharmacological blockade of local OXTRs in the LS and chemogenetic silencing of supraoptic nucleus OXTergic afferents to the LS increased social fear expression in lactating mice. Hence, LS-projecting OXT neurons suppress social fear in female mice.

KEYWORDS:

GABA; chemogenetics; cued fear conditioning; hypothalamus; lactation; lateral septum; oxytocin receptor; paraventricular nucleus; social fear conditioning; supraoptic nucleus

PMID:
29551417
DOI:
10.1016/j.cub.2018.02.044

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