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Psychoneuroendocrinology. 2018 May;91:123-131. doi: 10.1016/j.psyneuen.2018.02.035. Epub 2018 Mar 1.

Morphine reduced perceived anger from neutral and implicit emotional expressions.

Author information

1
Department of Psychology, University of Oslo, Norway. Electronic address: g.e.loseth@psykologi.uio.no.
2
Department of Diagnostic Physics, Division of Radiology and Nuclear Medicine, Oslo University Hospital, Norway; Division of Mental Health and Addiction, Oslo University Hospital, Norway.
3
Department of Psychology, University of Oslo, Norway.
4
Department of Forensic Medicine, Oslo University Hospital, Norway.
5
Department of Diagnostic Physics, Division of Radiology and Nuclear Medicine, Oslo University Hospital, Norway.

Abstract

The μ-opioid system modulates responses to pain and psychosocial stress and mediates non-social and social reward. In humans, the μ-opioid agonist morphine can increase overt attention to the eye-region and visual exploration of faces with neutral expressions. However, little is known about how the human μ-opioid system influences sensitivity to and appraisal of subtle and explicit cues of social threats and reward. Here, we examined the effects of selective μ-opioid stimulation on perception of anger and happiness in faces with explicit, neutral or implicit emotion expressions. Sixty-three healthy adults (32 females) attended two sessions where they received either placebo or 10 mg per oral morphine in randomised order under double-blind conditions. Based on the known μ-opioid reduction of pain and discomfort, as well as reports suggesting that the non-specific partial agonist buprenorphine or the non-specific antagonist naltrexone affect appraisal of social emotional stimuli, we hypothesised that morphine would reduce threat sensitivity and enhance perception of happy facial expressions. While overall perception of others' happiness was unaffected by morphine treatment, morphine reduced perception of anger in stimuli with neutral and implicit expressions without affecting perception of explicit anger. This effect was statistically unrelated to gender, subjective drug effects, mood and autism trait measures. The finding that a low dose of μ-agonist reduced the propensity to perceive anger in photos with subtle facial expressions is consistent with the notion that μ-opioids mediate social confidence and reduce sensitivity to threat cues.

KEYWORDS:

Autism traits; Emotion perception; Emotion recognition; Morphine; Opioid; Social cognition; μ-opioid

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