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Atherosclerosis. 2018 May;272:54-59. doi: 10.1016/j.atherosclerosis.2018.02.037. Epub 2018 Mar 2.

Influence of cardiovascular risk factors on longitudinal motion of the common carotid artery wall.

Author information

1
Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland; Department of Clinical Physiology and Nuclear Medicine, University of Eastern Finland, Kuopio, Finland. Electronic address: helena.taivainen@kuh.fi.
2
Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland; Department of Radiology, Kanta-Häme Central Hospital, Hämeenlinna, Finland; Department of Applied Physics, University of Eastern Finland, Kuopio, Finland.
3
Department of Medicine, University of Turku, Turku, Finland; Division of Medicine, Turku University Hospital, Turku, Finland; Murdoch Children's Research Institute, Parkville, Victoria, Australia.
4
Department of Clinical Physiology, University of Tampere and Tampere University Hospital, Tampere, Finland.
5
Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland; Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland.
6
Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland.
7
Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland; Department of Clinical Physiology and Nuclear Medicine, University of Eastern Finland, Kuopio, Finland.

Abstract

BACKGROUND AND AIMS:

Carotid artery longitudinal wall motion (CALM) is a new biomarker, which can be measured together with carotid intima-media thickness and distensibility measurements in the same session. Our objective was to study the relationship between these indicators of vascular health and cardiovascular risk factors in a large and well-characterized study population.

METHODS:

The study population consisted of 465 subjects aged 30-45 years. Successful measurements were performed in 287 participants.

RESULTS:

The peak-to-peak and retrograde amplitudes of the longitudinal motion were inversely correlated with systolic blood pressure (SBP; r = -0.152, p<0.05 and r = -0.189, p<0.01), diastolic blood pressure (DBP; r = -0.170, p<0.01 and r = -0.256, p<0.001) and body mass index (BMI; r = -0.158, p<0.01 and r = -0.291, p<0.001). In addition, retrograde amplitude of longitudinal motion indirectly correlated with total cholesterol and triglycerides (r = -0.163, p<0.01 and r = -0.228, p<0.001, respectively). Amplitude of antegrade longitudinal motion was directly correlated with DBP, total cholesterol, LDL-cholesterol, triglycerides and BMI (r = 0.198-0.274, p<0.001 for all). Antegrade longitudinal motion increased and retrograde longitudinal motion decreased with the increasing number of cardiovascular risk factors.

CONCLUSIONS:

The magnitude of correlation coefficients between CALM parameters and risk factors was comparable with those for carotid intima-media thickness and distensibility. However, the correlation profile for various risk factors was different and CALM gives additional information regarding arteriosclerosis and risk factors.

KEYWORDS:

Arterial stiffness; Arteriosclerosis; Cardiovascular risk factors; Carotid artery distensibility; Intima-media thickness; Motion tracking; Ultrasound imaging

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