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Am J Med Sci. 2018 Mar;355(3):293-298. doi: 10.1016/j.amjms.2017.07.007. Epub 2017 Jul 20.

Antiphospholipid Antibodies and Heart Valve Disease in Systemic Lupus Erythematosus.

Author information

1
Department of Medicine, Medical University of South Carolina, Charleston, SC.
2
Department of Medicine, Medical University of South Carolina, Charleston, SC. Electronic address: ruizda@musc.edu.

Abstract

Evaluation of antiphospholipid antibodies (aPL) and correlation with heart valve abnormalities among patients with systemic lupus erythematosus (SLE). Nested case-control study was conducted with 70 patients with SLE selected from a longitudinal database based on levels of aPL and presence or absence of valve disease by echocardiogram. Valvular abnormalities observed were regurgitation (52), other (14), artificial valves (4), stenosis (2), thickening (2) and no Libman-Sacks endocarditis (0). The mitral valve was the most commonly affected (30 abnormalities), followed by the tricuspid (20 abnormalities). Multivariate logistic regression for those with and without an aPL value ≥20 units/mL, adjusted for disease duration and age, showed significant differences for any valve abnormality (odds ratio [OR] = 3.1; 95% CI: 1.0-8.9; P = 0.041) and individually for the tricuspid valve (OR = 3.3; 95% CI: 1.0-11.1; P = 0.052) but not for the mitral valve (OR = 2.1; 95% CI: 0.68-6.45; P = 0.195). Levels of aPL ≥20 units/mL showed no association with aortic (P = 0.253), pulmonic (P = 1.000), tricuspid (P = 0.127), or mitral (P = 0.249) valve abnormalities. Levels of aPL correlate with certain valvular abnormalities among patients with SLE.

KEYWORDS:

Antiphospholipid antibodies; Antiphospholipid syndrome; Heart valve diseases; Systemic lupus erythematosus

PMID:
29549933
PMCID:
PMC5863618
DOI:
10.1016/j.amjms.2017.07.007
[Indexed for MEDLINE]
Free PMC Article

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