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Brain Behav Immun. 2018 May;70:3-4. doi: 10.1016/j.bbi.2018.03.017. Epub 2018 Mar 13.

The potential of treating Gulf War Illness with curcumin.

Author information

1
J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL 32611, USA.
2
J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL 32611, USA; Neuroscience Department and McKnight Brain Institute, University of Florida, Gainesville, FL 32611, USA. Electronic address: bormerod@bme.ufl.edu.

Abstract

A large proportion of Gulf War Veterans suffer from Gulf War Illness (GWI) - a devastating chronic disorder characterized by heterogeneous fatigue, pain and neuropsychological symptoms. In their recent Brain, Behavior and Immunity publication entitled "Curcumin Treatment Leads to Better Cognitive and Mood Function in a Model of Gulf War Illness with Enhanced Neurogenesis, and Alleviation of Inflammation and Mitochondrial Dysfunction in the Hippocampus", Kodali and colleagues (2018) report that the polyphenol curcumin improves cognition and mood in a rat model of GWI, potentially by increasing the expression of antioxidant genes and by reversing the effects of chronic combined acetylcholinesterase inhibitor exposure on neuroinflammation, mitochondrial respiration and hippocampal neurogenesis. This preclinical work is encouraging for our veterans who suffer chronically from GWI as well as for developing strategies to protect our troops during future deployments in similar environments.

KEYWORDS:

Antioxidant; Curcumin; Gulf War Illness; Memory; Mood; Neurogenesis

PMID:
29548999
DOI:
10.1016/j.bbi.2018.03.017
[Indexed for MEDLINE]

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